29. Madl CM,** Wang YX, Holbrook C, Su S, Shi X, Byfield FJ, Wicki G, Flaig IA, Blau HM.** Hydrogel biomaterials that stiffen and soften on demand reveal that skeletal muscle stem cells harbor a mechanical memory. PNAS. 2024;121(35):e2406787121. (Link, PubMed) [**co-corresponding authors]

28. Hidalgo-Alvarez V and Madl CM. Leveraging Biomaterial Platforms to Study Aging-Related Neural and Muscular Degeneration. Biomolecules. 2024;14(1):69. (Link, PubMed)

27. LeSavage BL, Zhang D, Huerta-López C, Gilchrist AE, Krajina BA, Karlsson K, Smith AR, Karagyozova K, Klett KC, Huang MS, Long C, Kaber G, Madl CM, Bollyky PL, Curtis C, Kuo CJ, Heilshorn SC. Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids through hyaluronan-CD44 interactions. Nature Materials. 2024;23:1138-1149. (Link, PubMed)

26. Madl CM. Accelerating aging with dynamic biomaterials: Recapitulating aged tissue phenotypes in engineered platforms. iScience. 2023;26(6):106825. (Link, PubMed)

25. Togninalli M,* Ho ATV,* Madl CM,* Holbrook CA, Wang YX, Magnusson KEG, Kirillova A, Chang A, Blau HM. Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors. npj Regenerative Medicine. 2023;8:4. (Link, PubMed) [*co-first authors]

24. Madl CM, Flaig IA, Holbrook CA, Wang YX, Blau HM. Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments. Biomaterials. 2021;275:120973. (Link, PubMed)

23. Madl CM, LeSavage BL, Khariton M, Heilshorn SC. Neural progenitor cells alter chromatin organization and neurotrophin expression in response to 3D matrix degradability. Advanced Healthcare Materials. 2020;9(18): 2000754. (Link, PubMed)

22. Madl AC, Madl CM, Myung D. Injectable cucurbit[8]uril-based supramolecular gelatin hydrogels for cell encapsulation. ACS Macro Letters. 2020;9(4):619-626. (Link, PubMed)

21. Madl CM** and Heilshorn SC. Rapid Diels-Alder cross-linking of cell encapsulating hydrogels. Chemistry of Materials. 2019;31(19):8035-8043. (Link, PubMed) [**corresponding author]

20. Madl CM, LeSavage BL, Dewi RE, Lampe KJ, Heilshorn SC. Matrix remodeling enhances the differentiation capacity of neural progenitor cells in 3D hydrogels. Advanced Science. 2019;6:1801716. (Link, PubMed)

19. Madl CM, Heilshorn SC, Blau HM. Bioengineering strategies to accelerate stem cell therapeutics. Nature. 2018;557:335-342. (Link, PubMed)

18. Madl CM, Katz LM, Heilshorn SC. Tuning bulk hydrogel degradation by simultaneous control of proteolytic cleavage kinetics and hydrogel network architecture. ACS Macro Letters. 2018;7:1302-1307. (Link, PubMed)

17. LeSavage BL, Suhar NA, Madl CM, Heilshorn SC. Production of elastin-like protein hydrogels for encapsulation and immunostaining of cells in 3D. Journal of Visualized Experiments. 2018;135:e57739. (Link, PubMed)

16. Haugh MG, Vaughan TJ, Madl CM, Raftery RM, McNamara LM, O'Brien FJ, Heilshorn SC. Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates. Biomaterials. 2018;171:23-33. (Link, PubMed)

15. Madl CM and Heilshorn SC. Bioorthogonal strategies for engineering extracellular matrices. Advanced Functional Materials. 2018;28(11):1706046. (Link, PubMed)

14. Madl CM and Heilshorn SC. Engineering hydrogel microenvironments to recapitulate the stem cell niche. Annual Review of Biomedical Engineering. 2018;20:21-47. (Link, PubMed)

13. Madl CM, LeSavage BL, Dewi RE, Dinh CB, Stowers RS, Khariton M, Lampe KJ, Nguyen D, Chaudhuri O, Enejder A, Heilshorn SC. Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodeling. Nature Materials. 2017;16:1233-1242. (Link, PubMed, News & Views)

12. Cipitria A, Boettcher K, Schoenhals S, Garske DS, Schmidt-Bleek K, Ellinghaus A, Dienelt A, Peters A, Mehta M, Madl CM, Huebsch N, Mooney DJ, Duda GN. In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect. Acta Biomaterialia. 2017;60:50-63. (Link)

11. Madl CM and Heilshorn SC. Tyrosine-selective functionalization for bio-orthogonal cross-linking of engineered protein hydrogels. Bioconjugate Chemistry. 2017;28(3):724-730. (Link, PubMed)

10. Mascharak S, Benitez PL, Proctor AC, Madl CM, Hu K, Dewi RE, Butte M, Heilshorn SC. YAP-dependent mechanotransduction is required for proliferation and migration on native-like substrate topography. Biomaterials. 2017;115:155-166. (Link, PubMed)

9. Madl CM, Katz LM, Heilshorn SC. Bio-orthogonally crosslinked, engineered protein hydrogels with tunable mechanics and biochemistry for cell encapsulation. Advanced Functional Materials. 2016;26(21):3612-3620. (Link, PubMed)

8. Huebsch N, Lippens E, Lee K, Mehta M, Koshy S, Darnell M, Desai R, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ. Matrix elasticity of void-forming hydrogels controls transplanted stem-cell mediated bone formation. Nature Materials. 2015;14(12):1269-1277. (Link, PubMed)

7. Mehta M*, Madl CM*, Lee S, Duda GN, Mooney DJ. The collagen I mimetic peptide DGEA enhances an osteogenic phenotype in mesenchymal stem cells when presented from cell-encapsulating hydrogels. Journal of Biomedical Materials Research Part A. 2015;103(11): 3516-3525. (Link, PubMed) [*co-first authors]

6. Madl CM and Heilshorn SC. Matrix interactions modulate neurotrophin-mediated neurite outgrowth and pathfinding. Neural Regeneration Research. 2015;10(4):514-517. (Link, PubMed)

5. Romano NH*, Madl CM*, Heilshorn SC. Matrix RGD ligand density and L1CAM-mediated Schwann cell interactions synergistically enhance neurite outgrowth. Acta Biomateriala. 2015;11:48-57. (Link, PubMed) [*co-first authors]

4. Madl CM*, Keeney M*, Li X, Han L-H, Yang F. Co-release of cells and polymeric nanoparticles from sacrificial microfibers enhances nonviral gene delivery inside 3D hydrogels. Tissue Engineering Part C. 2014;20(10):798-805. (Link) [*co-first authors]

3. Madl CM, Mehta M, Duda GN, Heilshorn SC, Mooney DJ. Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells. Biomacromolecules. 2014;15:445-455. (Link, PubMed)

2. Kariuki PN, Madl CM, Martin JJ, Upreti S, Jones WE. Synthesis and bonding of trans-dichlorobis(1,3-diaminopropane)ruthenium(III) chloride to a self assembled monolayer and its effect on conducting polymer sheet conductivity. Inorganica Chimica Acta. 2012;383:320-326. (Link)

1. Madl CM, Kariuki PN, Gendron J, Piper LFJ, Jones WE. Vapor phase polymerization of poly(3,4-ethylenedioxythiophene) on flexible substrates for enhanced transparent electrodes. Synthetic Metals. 2011;161:1159-1165. (Link)

1. Mulyasasmita W, Madl CM, Heilshorn SC. "Protein-Engineered Biomaterials: Synthesis and Characterization." Eds. Ducheyne P, Healy K, Hutmacher DW, Grainger DW, Kirkpatrick CJ, Comprehensive Biomaterials II. Oxford, UK, Elsevier Science. 2017. (Link)

1. Madl CM and Heilshorn SC. Probing the metabolomics of stem cell differentiation with biomaterials. Chem. 2016;2:192-194. (Link)