Mechanically-Induced Dysfunction in Muscle Stem Cells
We are leveraging protein-engineered materials in combination with triggerable bioorthogonal chemistries to model changes in the mechanical microenvironment of muscle stem cells to identify how aberrant mechanotransduction can diminish muscle stem cell function during aging.
Biophysical Regulation of Neurogenesis
We are developing hydrogel materials with on-demand tuning of network dynamics to determine how altered biophysical cues in aging and neurodegenerative diseases lead to neural stem cell dysfunction and impaired neurogenesis.
